In our recent question and also answer, the pharmacist discusses even if it is or not Benadryl (diphenhydramine) can be taken with Sudafed (pseudoephedrine).

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Jerome asked

I have really negative congestion and also am acquisition Sudafed (pseudoephedrine) which really seems to be helping. Ns am having trouble sleeping and also was wonder if it was safe to take Benadryl too. I am taking Sudafed 12 hour.


Sudafed (pseudoephedrine) and also Benadryl (diphenhydramine) can be safe taken with each other as over there is no interaction between the two medications. In fact, there are products easily accessible over the counter that incorporate both ingredients to ease management of both drugs.

Taking Benadryl and also Sudafed Together

Sudafed (pseudoephedrine) is a generally used nasal decongestant that functions by developing vasoconstriction in the nasal passages, i beg your pardon shrinks swollen nasal membranes and also relieves nasal congestion. Sudafed likewise acts to rise nasal airflow and also drainage the sinus secretions.

Sudafed is frequently well tolerated, however one that the most typical adverse reactions to that is insomnia. Sudafed can have a slim stimulating effect in some, making it an overwhelming to fall asleep easily. In fact, insomnia has actually a report incidence price of in between 4% to 10% based upon data derived from studies.

To combat the effects insomnia, Benadryl (diphenhydramine) is a potential option. In addition to its use as an antihistamine, the is an efficient sleep aide. Benadryl can reason pronounced sedation upon management and can assist in diminish sleep latency (i.e. Time that takes to fall asleep.) over there is no interaction in between Benadryl and Sudafed and also they are safe to take it together.

As mentioned above, there are numerous over the counter commodities that save on computer bothingredients if you space looking to combine the 2 medications. However, countless were discontinued as an outcome of thestricter lawsregarding Sudafed purchases. Many assets that originally contained pseudoephedrine now contain Sudafed PE (phenylephrine).While there still may be Benadryl (diphenhydramine)/Sudafed (pseudoephedrine) combinations available to purchase, that is much more common to view Benadryl and also Sudafed PE (phenylephrine) merged with one another as these assets are obtainable to be inserted on store shelves and also not behind the pharmacy counter.

It is crucial to note that if you room taking Sudafed and using Benadryl as a night time sleep aide, the overall effects that Benadryl may be diminished (based top top the stimulant impact of Sudafed). They can nevertheless be offered together however, as discussed above.

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Sudafed is accessible in immediate release formulations, which last roughly four to 6 hours and extended release (e.g. 12 and also 24 hour) formulations. If you are still having trouble resting while acquisition Sudafed and Benadryl, the is frequently prudent to protect against taking instant release Sudafed assets within 4 to 6 hours of bedtime and extended release Sudafed products up to 12 hours prior to bedtime.